Advances in the regulatory mechanisms of mTOR in necroptosis
The mammalian target of rapamycin (mTOR), an evolutionarily highly conserved serine/threonine protein kinase, plays a prominent role in controlling gene expression, metabolism, and cell death.Programmed cell death (PCD) is indispensable for maintaining homeostasis by removing senescent, defective, or malignant cells.Necroptosis, a type of PCD, reli